How We Handle Situations That Do Not Fit The Guide

You read the guide, and your situation does not match it. The question is what to do with the part that no longer applies.
Why standard advice gets amended
Complicated situations call for changes to standard advice. That is the reason these notes exist, and it sets their focus: interacting constraints, competing priorities, and the compromises a simple guide leaves out.
Published guidance is the starting material. The American Society of Plastic Surgeons chemical peel page is an example of the kind of source that gets read against a reader's real constraints.
How the comparison works
The method is to compare published guidance with documented complex cases to show which assumptions no longer hold. Guidance goes on one side. The complication goes on the other. The notes then report what survives.
Readers who want to see the kind of guidance involved can start with the ASPS page on botulinum toxin results and the PMC paper on botulinum toxin type A for facial wrinkles.
Who the notes are for
The notes are written for readers in Ypsilanti, Michigan whose situation is messier than the handout, and they keep their claims close to what the published sources say.
The assumptions worth testing
Does the timeline in the handout fit your calendar? Does the list of side effects cover your case? Does the advice assume a reader who matches the average?
For a consensus-level view of one treatment area, read the Global Aesthetics Consensus on botulinum toxin type A.